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Sphingosine kinase signalling in immune cells: Potential as novel therapeutic targets

Alirio J. Melendez

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2008

Langue:

english

Fichier:

PDF, 809 KB

english, 2008

Sphingosine kinase signalling in immune cells

Tay Hwee Kee, Patricia Vit, Alirio J Melendez

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2005

Langue:

english

Fichier:

PDF, 122 KB

english, 2005

Allergy therapy: The therapeutic potential of targeting sphingosine kinase signalling in mast cells

Alirio J. Melendez

Journal:

European Journal of Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 198 KB

english, 2008

Retracted: Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes

Liang Zhi, Bernard P. Leung, Alirio J. Melendez

Journal:

Journal of Cellular Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 216 KB

english, 2006

Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: Microarray and proteomics analyses in cultured murine cortical neurons

Chor Hui Vivien Koh, Zhao Feng Peng, Keli Ou, Alirio Melendez, Jayapal Manikandan, Robert Z. Qi, Nam Sang Cheung

Journal:

Journal of Cellular Physiology

Année:

2007

Langue:

english

Fichier:

PDF, 870 KB

english, 2007

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin

Meng Shyan Choy, Minghui Jessica Chen, Jayapal Manikandan, Zhao Feng Peng, Andrew M. Jenner, Alirio J. Melendez, Nam Sang Cheung

Journal:

Journal of Cellular Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 530 KB

english, 2011

Gene profiling reveals hydrogen sulphide recruits death signaling via the N-methyl-D-aspartate receptor identifying commonalities with excitotoxicity

Minghui Jessica Chen, Zhao Feng Peng, Jayapal Manikandan, Alirio J. Melendez, Gek San Tan, Ching Ming Chung, Qiu-Tian Li, Theresa M. Tan, Lih Wen Deng, Matthew Whiteman, Philip M. Beart, Phillip K. Mo

Journal:

Journal of Cellular Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 460 KB

english, 2011

C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcγRI)

Katherine B. Bodman-Smith, Alirio J. Melendez, Ian Campbell, Patrick T. Harrison, Janet M. Allen, John G. Raynes

Journal:

Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 195 KB

english, 2002

SHORT INTEFERING RNA (siRNA) AS A NOVEL THERAPEUTIC

Peter N Pushparaj, Alirio J Melendez

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 134 KB

english, 2006

INTRODUCTION

WS Fred Wong, Alirio J Melendez

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 43 KB

english, 2006

DNA MICROARRAY TECHNOLOGY FOR TARGET IDENTIFICATION AND VALIDATION

Manikandan Jayapal, Alirio J Melendez

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 186 KB

english, 2006

Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis

Elaine Hau Jin Yew, Nam Sang Cheung, Meng Shyan Choy, Robert Z. Qi, Alan Yiu-Wah Lee, Zhao Feng Peng, Alirio J. Melendez, Jayapal Manikandan, Evelyn Siew-Chuan Koay, Lily-Lily Chiu, Wooi Loon Ng, Matt

Journal:

Journal of Neurochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 402 KB

english, 2005

The helminth product ES-62 protects against septic shock via Toll-like receptor 4–dependent autophagosomal degradation of the adaptor MyD88

Puneet, Padmam, McGrath, Mairi A, Tay, Hwee Kee, Al-Riyami, Lamyaa, Rzepecka, Justyna, Moochhala, Shabbir M, Pervaiz, Shazib, Harnett, Margaret M, Harnett, William, Melendez, Alirio J

Journal:

Nature Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2011

Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

Melendez, Alirio J, Harnett, Margaret M, Pushparaj, Peter N, Wong, WS Fred, Tay, Hwee Kee, McSharry, Charles P, Harnett, William

Journal:

Nature Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 320 KB

english, 2007

Retraction: Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes

Liang Zhi, Bernard P. Leung, Alirio J. Melendez

Journal:

Journal of Cellular Physiology

Année:

2012

Langue:

english

Fichier:

PDF, 40 KB

english, 2012

U18666A-mediated apoptosis in cultured murine cortical neurons: Role of caspases, calpains and kinases

Chor Hui Vivien Koh, Robert Z. Qi, Dianbo Qu, Alirio Melendez, Jayapal Manikandan, Boon Huat Bay, Wei Duan, Nam Sang Cheung

Journal:

Cellular Signalling

Année:

2006

Langue:

english

Fichier:

PDF, 675 KB

english, 2006

OR.84. Role of Phospholipase D in T Cell Receptor Signalling Pathway Triggered by T Cell Receptor

Moizza Mansoor, Alirio Melendez

Journal:

Clinical Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 56 KB

english, 2008

A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic–reperfusion injury

Minghui Jessica Chen, Connie H.Y. Wong, Zhao Feng Peng, Jayapal Manikandan, Alirio J. Melendez, Theresa M. Tan, Peter J. Crack, Nam Sang Cheung

Journal:

Free Radical Biology and Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 756 KB

english, 2011

Crosstalk between ARF6 and protein kinase Cα in FcγRI-mediated activation of phospholipase D1

Alirio J. Melendez, Margaret M. Harnett, Janet M. Allen

Journal:

Current Biology

Année:

2001

Langue:

english

Fichier:

PDF, 243 KB

english, 2001

A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium

Alirio Melendez, R.Andres Floto, Angus J. Cameron, David J. Gillooly, Margaret M. Harnett, Janet M. Allen

Journal:

Current Biology

Année:

1998

Langue:

english

Fichier:

PDF, 176 KB

english, 1998

Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades

Zhao Feng Peng, Minghui Jessica Chen, Jayapal Manikandan, Alirio J. Melendez, Guanghou Shui, Françoise Russo-Marie, Matthew Whiteman, Philip M. Beart, Philip K. Moore, Nam Sang Cheung

Journal:

Journal of Cellular and Molecular Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2012

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responses

Manikandan Jayapal, Hwee Kee Tay, Renji Reghunathan, Liang Zhi, Kah Kiong Chow, Mary Rauff, Alirio J Melendez

Journal:

BMC Genomics

Année:

2006

Langue:

english

Fichier:

PDF, 558 KB

english, 2006

Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome

Renji Reghunathan, Manikandan Jayapal, Li-Yang Hsu, Hiok-Hee Chng, Dessmon Tai, Bernard P Leung, Alirio J Melendez

Journal:

BMC Immunology

Année:

2005

Langue:

english

Fichier:

PDF, 437 KB

english, 2005

Phospholipase D and immune receptor signalling

Alirio J. Melendez, Janet M. Allen

Journal:

Seminars in Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 164 KB

english, 2002

Refining siRNA in vivo transfection: Silencing SPHK1reveals its key role in C5a-induced inflammation in vivo

Peter N. Pushparaj, Shiau Chen H’ng, Alirio J. Melendez

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2008

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2008

Environmental toxicogenomics: A post-genomic approach to analysing biological responses to environmental toxins

Manikandan Jayapal, Rabindra N. Bhattacharjee, Alirio J. Melendez, M. Prakash Hande

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2010

Langue:

english

Fichier:

PDF, 708 KB

english, 2010

Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis

Yann Wan Yap, Minghui Jessica Chen, Meng Shyan Choy, Zhao Feng Peng, Matthew Whiteman, Jayapal Manikandan, Alirio J. Melendez, Nam Sang Cheung

Journal:

Life Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 496 KB

english, 2010

Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: Transcriptional responses and cellular pathways

Zhao Feng Peng, Chor Hui Vivien Koh, Qiu Tian Li, Jayapal Manikandan, Alirio J. Melendez, Soon Yew Tang, Barry Halliwell, Nam Sang Cheung

Journal:

Neuropharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 851 KB

english, 2007

Proteasome inhibition: An early or late event in nitric oxide-induced neuronal death?

Zhao Feng Peng, Minghui Jessica Chen, Yann Wan Yap, Jayapal Manikandan, Alirio J. Melendez, Meng Shyan Choy, Philip K. Moore, Nam Sang Cheung

Journal:

Nitric Oxide

Année:

2008

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2008

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

Alirio J. Melendez, Estelle Carlos-Dias, Mark Gosink, Janet M. Allen, Laszlo Takacs

Journal:

Gene

Année:

2000

Langue:

english

Fichier:

PDF, 360 KB

english, 2000

The helminth product ES-62 protects against septic shock via Toll-like receptor 4–dependent autophagosomal degradation of the adaptor MyD88

Puneet, Padmam, McGrath, Mairi A, Tay, Hwee Kee, Al-Riyami, Lamyaa, Rzepecka, Justyna, Moochhala, Shabbir M, Pervaiz, Shazib, Harnett, Margaret M, Harnett, William, Melendez, Alirio J

Journal:

Nature Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 75 KB

english, 2011

Retraction notice to “Refining siRNA in vivo transfection: Silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo” [Int. J. Biochem. Cell Biol. 40 (2008) 1817–1825]

Pushparaj, Peter N., H’ng, Shiau Chen, Melendez, Alirio J.

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2013

Langue:

english

Fichier:

PDF, 133 KB

english, 2013

Retraction notice to “Environmental toxicogenomics: A post-genomic approach to analysing biological responses to environmental toxins” [Int. J. Biochem. Cell Biol. 42 (2010) 230–240]

Jayapal, Manikandan, Bhattacharjee, Rabindra N., Melendez, Alirio J., Hande, M. Prakash

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2013

Langue:

english

Fichier:

PDF, 173 KB

english, 2013

Aggregation of the Human High Affinity Immunoglobulin G Receptor (Fcγ RI) Activates both Tyrosine Kinase and G Protein-Coupled Phosphoinositide 3-Kinase Isoforms

Alirio J. Melendez, David J. Gillooly, Margaret M. Harnett and Janet M. Allen

Journal:

Proceedings of the National Academy of Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 1.67 MB

english, 1998

Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases

Wong, Lingkai, Tan, Sheryl S. L., Lam, Yulin, Melendez, Alirio J.

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 943 KB

english, 2009

FcγRI-triggered Generation of Arachidonic Acid and Eicosanoids Requires iPLA 2 but Not cPLA 2 in Human Monocytic Cells

Tay, Hwee Kee, Melendez, Alirio J.

Journal:

Journal of Biological Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2004

REQUEST FOR RETRACTION: SHORT INTERFERING RNA (siRNA) AS A NOVEL THERAPEUTIC

Melendez-Romero, Alirio

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2013

Langue:

english

Fichier:

PDF, 95 KB

english, 2013

Phagocytosis: a repertoire of receptors and Ca2+ as a key second messenger

Melendez, Alirio J., Tay, Hwee Kee

Journal:

Bioscience Reports

Année:

2008

Langue:

english

Fichier:

PDF, 432 KB

english, 2008

New developments on the TNFα-mediated signalling pathways

Sethu, Swaminathan, Melendez, Alirio J.

Journal:

Bioscience Reports

Année:

2011

Langue:

english

Fichier:

PDF, 396 KB

english, 2011

Role of Cell Adhesion Molecules and Immune-Cell Migration in the Initiation, Onset and Development of Atherosclerosis

Chi, Zhang, Melendez, Alirio J.

Journal:

Cell Adhesion & Migration

Année:

2007

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2007

Water and Ion Channels: Crucial in the Initiation and Progression of Apoptosis in Central Nervous System?

Chen, Minghui, Sepramaniam, Sugunavathi, Armugam, Arunmozhiarasi, Choy, Meng, Manikandan, Jayapal, Melendez, Alirio, Jeyaseelan, Kandiah, Cheung, Nam

Journal:

Current Neuropharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 263 KB

english, 2008

Recent Trials for FTY720 (Fingolimod): A New Generation of Immunomodulators Structurally Similar to Sphingosine

Melendez, Alirio, Mansoor, Moizza

Journal:

Reviews on Recent Clinical Trials

Année:

2008

Langue:

english

Fichier:

PDF, 240 KB

english, 2008

Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities

GILLOOLY, David J., MELENDEZ, Alirio J., HOCKADAY, Austin R., HARNETT, Margaret M., ALLEN, Janet M.

Journal:

Biochemical Journal

Année:

1999

Langue:

english

Fichier:

PDF, 275 KB

english, 1999

Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities

GILLOOLY, David J., MELENDEZ, Alirio J., HOCKADAY, Austin R., HARNETT, Margaret M., ALLEN, Janet M.

Journal:

Biochemical Journal

Année:

1999

Langue:

english

Fichier:

PDF, 275 KB

english, 1999

FcγRI DIFFERENTIALLY ACTIVATES SEVERAL PKC ISOFORMS AND DIFFERENT PHOSPHOLIPASES DEPENDING ON MONOCYTE DIFFERENTIATION

Melendez, Alirio J., Harnett, Margaret M., Allen, Janet M.

Journal:

Biochemical Society Transactions

Année:

1999

Langue:

english

Fichier:

PDF, 116 KB

english, 1999

Advances in Antisense Oligonucleotide Development for Target Identification, Validation, and as Novel Therapeutics

Mansoor, Moizza, Melendez, Alirio J.

Journal:

Gene Regulation and Systems Biology

Année:

2008

Langue:

english

Fichier:

PDF, 308 KB

english, 2008

Genome activity profiling of monomeric-IgE and Fc-epsilon-RI-aggregation on human mast cells reveals a complex network of genes involved in inflammatory responses.

Manikandan, Jayapal, Melendez, Alirio Jose, Pushparaj, Peter Natesan

Journal:

Bioentrepreneur

Année:

2007

Langue:

english

Fichier:

PDF, 462 KB

english, 2007

Differences in the gene expression profile of human monocytic cells activated by high and low affinity Fc-gamma-receptors.

Manikandan, Jayapal, Reghunathan, Renji, Melendez, Alirio Jose, Pushparaj, Peter Natesan

Journal:

Bioentrepreneur

Année:

2007

Langue:

english

Fichier:

PDF, 328 KB

english, 2007

Differential Gene Expression of Human Mast cell Activation Reveals Gene profiles of Innate and Adaptive Immunity.

Manikandan, Jayapal, Renji, Reghunathan, Pushparaj, Peter Natesan, Melendez, Alirio Jose

Journal:

Bioentrepreneur

Année:

2007

Langue:

english

Fichier:

PDF, 258 KB

english, 2007

siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy.

Manikandan, Jayapal, Pushparaj, Peter Natesan, Melendez, Alirio Jose

Journal:

Bioentrepreneur

Année:

2007

Langue:

english

Fichier:

PDF, 324 KB

english, 2007